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Benzodiazepines - Central nervous method and/or respiratory-depressant results could possibly be additively or synergistically present. The 2 substances potentiate each other strongly and unpredictably, incredibly quickly resulting in unconsciousness.
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MAOIs - Coadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has actually been connected with scarce reviews of critical adverse reactions. There look like two varieties of interaction, an excitatory plus a depressive 1.
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O-Desmethyltramadol is atypical as it is actually located in a racemate (mixture) of its stereoisomers. Stereoisomers are two molecules that share precisely the same chemical structure, but are a few-dimensional mirror photographs of one another. Tramadol is manufactured as being a racemate of its two isomers simply because the combination is demonstrated being simpler.
GHB/GBL - The two substances potentiate one another strongly and unpredictably, quite promptly leading to unconsciousness. When unconscious, vomit aspiration is actually a hazard Otherwise placed while in the Restoration position
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Tramadol - Improved danger of seizures. Tramadol alone is known to induce seizures and it can have additive results on seizure threshold with other opioids. Central anxious program- and/or respiratory-depressant effects may be additively or synergistically present.
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